反应详情

Three g. 1-ethyl-4-hydroxypyrrolidin-2-one are dissolved in 30 ml. anhydrous pyridine and 2.7 ml. benzoyl chloride are added thereto. The reaction mixture is stirred overnight at ambient temperature, then it is poured into water containing 20 ml. concentrated sulphuric acid and extracted with ethyl acetate. The organic phases are collected, washed with a saturated aqueous solution of ammonium sulphate, evaporated to dryness and separated by chromatography to give 4.8 g. 1-ethyl-4-benzoyloxypyrrolidin-2-one; m.p. 53°-54° C.; Rf=0.27 (silica gel; eluant ethyl acetate).

1. extractionconcentrated sulphuric acid and extracted with ethyl acetate
2. customThe organic phases are collected
3. washwashed with a saturated aqueous solution of ammonium sulphate
4. customevaporated to dryness
5. customseparated by chromatography
6. customto give 4.8 g