反应详情

5.34 g of benzyl 4-pyridyl ketone and 3.75 g of hydroxylamine hydrochloride in 50 ml of pyridine are heated to boiling for 4 hours. After cooling, the mixture is stirred into 600 ml of water, and the oxime (5.6 g) of melting point 194°-196° C. is filtered off. The oxime is hydrogenated with hydrogen in isopropanol with Raney nickel at 50° C. and under normal pressure. After the customary working up, the amine is obtained as a pale yellow oil.

1. temperatureAfter cooling
2. filtrationthe oxime (5.6 g) of melting point 194°-196° C. is filtered off
3. customis hydrogenated with hydrogen in isopropanol with Raney nickel at 50° C. and under normal pressure