5-Phenylethyl-2-methylthio-4-pyrimidone → HCID 20262871, compound

HRID 464334Notes

Reaction equation

HRID 464334 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:6].CS[C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:17][N:16]=1>N1C=CC=CC=1>[CH3:6][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:17][N:16]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1

Participants

4

Reactant 2

HCID 129515085-Phenylethyl-2-methylthio-4-pyrimidoneHCID 20262876N~1~-Methyl-N~1~-(pyridin-2-yl)propane-1,3-diamine

Product 1

HCID 20262871HCID 20262871, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-[N-(3-aminopropyl)-N-methylamino]pyridine (0.81 g) and 2-methylthio-5-phenylethylpyrimid-4-one (1.0 g) were heated together under reflux in pyridine (2.5 ml) for 26 hr. After stripping, the residue was crystallised twice from ethanol and finally from acetone to give 2-[3-(N-methyl-N-pyrid-2-ylamino)propylamino]-5-phenylethylpyrimid-4-one, 0.68 g (46%) mp 134°-136° C.

Workup

  1. customthe residue was crystallised twice from ethanol and finally from acetone

Sources & evidence

ORD record
ord-c4a83da3c0ea43abaa72ad6767520951
Source dataset
uspto-grants-1985_10
Patent number
US04547506

Reaction notes

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