反应详情

2-[N-(3-aminopropyl)-N-methylamino]pyridine (1.0 g) and 2-methylthio-5-(4-bromobenzyl)pyrimid-4-one (1.56 g) were heated together under reflux in pyridine (3 ml) for 18 hr. The mixture was stripped and the residue recrystallised three times from ethanol to give 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(4-bromobenzyl)pyrimid-4-one, 1.45 g (67%) mp 178°-9° C.

1. customthe residue recrystallised three times from ethanol