HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Aminopropyl)-N-methylpyridin-2-amine → 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(4-bromobenzyl)pyrimid-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Aminopropyl)-N-methylpyridin-2-amine | HCID 20262876 | — |
| Reactant | 5-[(4-Bromophenyl)methyl]-2-(methylthio)-4(3H)-pyrimidinone | HCID 20262887 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(4-bromobenzyl)pyrimid-4-one | HCID 54208310 | — |
Reaction Steps
2-[N-(3-aminopropyl)-N-methylamino]pyridine (1.0 g) and 2-methylthio-5-(4-bromobenzyl)pyrimid-4-one (1.56 g) were heated together under reflux in pyridine (3 ml) for 18 hr. The mixture was stripped and the residue recrystallised three times from ethanol to give 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(4-bromobenzyl)pyrimid-4-one, 1.45 g (67%) mp 178°-9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547506 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-1c0600ab8bed4968a22d09b3116ed2e8 |
| Source note | uspto-grants-1985_10 |