反应详情

2-[N-(3-aminopropyl)-N-benzylamino]pyridine (1 g) and 2-nitroamino-5-(5,6-dimethylpyrid-3-ylmethyl)pyrimid-4-one (0.94 g) were heated together under reflux in pyridine (5 ml) for 20 hrs. After stripping the resulting solid was recrystallized from ethanol/water to give 2-[3-(N-benzyl-N-pyrid-2-ylamino)propylamino]-5-(5,6-dimethylpyrid-3-ylmethyl)pyrimid-4-one 0.75 H2O, 0.61 g (38%) m.p. 95°-99° C.

1. customwas recrystallized from ethanol/water