反应详情

2-[N-(3-aminopropyl)-N-propylamino]pyridine (1.0 g) and 2-methylthio-5-(4-methoxybenzyl)pyrimid-4-one (0.88 g) were fused together on an oil bath at 160° C. for 2.5 hr. On cooling the residue was crystallized from ethanol/water to give a white solid which on recrystallization from acetone/water gave 2-[3-(N-propyl-N-pyrid-2-ylamino)propylamino]-5-(4-methoxybenzyl)pyrimid-4-one 1 H2O; 1.27 g (79%) m.p. indeterminate.

1. temperatureOn cooling the residue
2. customwas crystallized from ethanol/water
3. customto give a white solid which
4. customon recrystallization from acetone/water