5-(4-Methoxybenzyl)-2-methylthio-4-pyrimidone → 2-[3-(N-propyl-N-pyrid-2-ylamino)propylamino]-5-(4-methoxybenzyl)pyrimid-4-one

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Reaction Steps

2-[N-(3-aminopropyl)-N-propylamino]pyridine (1.0 g) and 2-methylthio-5-(4-methoxybenzyl)pyrimid-4-one (0.88 g) were fused together on an oil bath at 160° C. for 2.5 hr. On cooling the residue was crystallized from ethanol/water to give a white solid which on recrystallization from acetone/water gave 2-[3-(N-propyl-N-pyrid-2-ylamino)propylamino]-5-(4-methoxybenzyl)pyrimid-4-one 1 H2O; 1.27 g (79%) m.p. indeterminate.

Provenance & Evidence