HuagongsheHuagongshe Chemistry Print Report · For research reference only
Quinoline → tert.-butyl(1R,cis)2,2-dimethyl-3-[(Z)-2-(methoxy carbonyl)-ethenyl]-cyclopropane carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Quinoline | HCID 7047 | — |
| Reactant | tert.-butyl(1R,cis)2,2-dimethyl-3-[2-(methoxy carbonyl)-ethynyl]-cyclopropane-carboxylate | HCID 12807746 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | tert.-butyl(1R,cis)2,2-dimethyl-3-[(Z)-2-(methoxy carbonyl)-ethenyl]-cyclopropane carboxylate | HCID 13253938 | 90.9% |
Reaction Steps
12 g of the product of Step A in 240 cm3 of ethyl acetate were hydrogenated in the presence of 2.4 g of 10% palladium hydroxide on barium sulfate and 2.4 cm3 of quinoline. The mixture was filtered and the filtrate was evaporated to dryness to obtain 11 g of tert.-butyl(1R,cis)2,2-dimethyl-3-[(Z)-2-(methoxy carbonyl)-ethenyl]-cyclopropane carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04547522 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-8712d796680a405a82d0a85619692533 |
| Source note | uspto-grants-1985_10 |