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HRID464446

反应详情

EQUATION

反应方程式

HRID 464446 的结构方程式

REACTANTS

反应物

2
结构：c1ccc2ncccc2c1
HCID7047

Quinoline

C9H7N

结构：COC(=O)C#C[C@H]1[C@@H](C(=O)OC(C)(C)C)C1(C)C
HCID12807746

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)/C=C\[C@H]1[C@@H](C(=O)OC(C)(C)C)C1(C)C
HCID13253938

未命名化合物

收率 90.9%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

12 g of the product of Step A in 240 cm3 of ethyl acetate were hydrogenated in the presence of 2.4 g of 10% palladium hydroxide on barium sulfate and 2.4 cm3 of quinoline. The mixture was filtered and the filtrate was evaporated to dryness to obtain 11 g of tert.-butyl(1R,cis)2,2-dimethyl-3-[(Z)-2-(methoxy carbonyl)-ethenyl]-cyclopropane carboxylate.

WORKUP

后处理

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated to dryness