反应详情

Method B A mixture of 400 g (0.96 mole) of 1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-phthalimidopropyne, 1.3 L of ethanol and 300 ml of 40% aqueous methylamine was stirred at room temperature for 2 hr. Dropwise 2.8 l of water was added, and the resulting precipitate was collected by filtration to give a pale yellow solid, mp 70°-80° C. Recrystallization from ether gave pale yellow prisms, mp 80°-91° C.

1. filtrationthe resulting precipitate was collected by filtration
2. customto give a pale yellow solid, mp 70°-80° C
3. customRecrystallization from ether
4. customgave pale yellow prisms, mp 80°-91° C.