反应详情

7 mmol of N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide in 30 ml of phosphorus oxychloride are stirred for 6 hours at 50°-60° C. When cooled, the reaction mixture is poured out on 300 ml of ice water and neutralized by the addition of concentrated ammonia solution with cooling. The product is extracted with ether and the combined ether extracts are washed, dehydrated and concentrated by evaporation. The solid residue is recrystallised from ether.

1. temperatureWhen cooled
2. temperaturewith cooling
3. extractionThe product is extracted with ether
4. washthe combined ether extracts are washed
5. concentrationconcentrated by evaporation
6. customThe solid residue is recrystallised from ether