反应详情

A solution of 7.6 g of 1-butyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione in 20 ml of acetic acid was refluxed for 2 hours. The solution was evaporated. The residue was refluxed in 40 ml of 2N NaOH for 2 hours and then neutralized with 5N HCl. The crystals were filtered off and recrystallized from 350 ml ethanol. Yield 1.8 g (21%) (XXXXVII) NMR (see Table I).

1. customThe solution was evaporated
2. temperatureThe residue was refluxed in 40 ml of 2N NaOH for 2 hours
3. filtrationThe crystals were filtered off
4. customrecrystallized from 350 ml ethanol