Triethylamine → HCID 86740380, compound

HRID 464632Notes

Reaction equation

HRID 464632 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[N:8]=[N:7][C:6]([CH2:9][O:10][CH2:11][C:12]2[NH:13][C:14]([CH3:35])=[C:15]([C:31]([O:33][CH3:34])=[O:32])[CH:16]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=3[Cl:30])[C:17]=2[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[N:5]1.C(N(CC)CC)C.[Cl:43][C:44]1[CH:49]=[C:48](Cl)[N:47]=[CH:46][N:45]=1>C(O)C>[Cl:43][C:44]1[N:45]=[CH:46][N:47]=[C:48]([NH:1][CH2:2][CH2:3][N:4]2[N:8]=[N:7][C:6]([CH2:9][O:10][CH2:11][C:12]3[NH:13][C:14]([CH3:35])=[C:15]([C:31]([O:33][CH3:34])=[O:32])[CH:16]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=4[Cl:30])[C:17]=3[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[N:5]2)[CH:49]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 709434,6-DichloropyrimidineHCID 70042414HCID 70042414, compound

Product 1

HCID 86740380HCID 86740380, compoundYield 80.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-(2-aminoethyl)-5-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxymethyl}tetrazole (0.52 g), triethylamine (0.5 ml) and 4,6-dichloropyrimidine (0.16 g) in ethanol (20 ml) was heated under reflux for 23 hours and then evaporated. The residue was purified by chromatography on silica (8 g) using dichloromethane plus from 0 to 100% by volume of ethyl acetate as eluant. Appropriate fractions were combined and evaporated to give 2-{[(6-chloro-4-pyrimidinyl)amino]ethyl}-5-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxymethyl}tetrazole (0.51 g) as a colourless foam. A solution of this crude product in morpholine (3 ml) was heated on a steam-bath for 90 minutes and then partitioned between 2M hydrochloric acid and dichloromethane. The acidic layer was extracted into dichloromethane and the combined organic layers were washed with water and 10% aqueous sodium carbonate solution, dried over anhydrous sodium sulphate and evaporated. The residue was purified by chromatography on silica (10 g) using dichloromethane plus from 0 to 50% by volume of ethyl acetate followed by dichloromethane plus from 1 to 5% by volume of methanol as eluant. Appropriate fractions were combined and evaporated. The residual oil was triturated with diethyl ether and the resulting solid collected, washed with diethyl ether and dried to give the title compound (0.51 g), m.p. 160°-162° C. Found: C,52.24; H,5.20; N,18.24. C30H35Cl2N9O6 requires: C,52.33; H,5.09; N,18.31%.

Workup

  1. temperatureunder reflux for 23 hours
  2. customevaporated
  3. customThe residue was purified by chromatography on silica (8 g)
  4. customevaporated

Sources & evidence

ORD record
ord-4860192adfb14a71a87d295c68d7cfb0
Source dataset
uspto-grants-1985_10
Patent number
US04548935

Reaction notes

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