1-(4-(3-Aminophenyl)thiazol-2-yl)guanidine → HCID 178512249, compound

HRID 464697Notes

Reaction equation

HRID 464697 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]>C(O)C>[C:5]([NH:9][CH:8]=[N:16][C:12]1[CH:13]=[CH:14][CH:15]=[C:10]([C:8]2[N:9]=[C:5]([NH:1][C:2]([NH2:4])=[NH:3])[S:6][CH:7]=2)[CH:11]=1)#[N:1]

Participants

3

Reactant 1

HCID 1785126111-(4-(3-Aminophenyl)thiazol-2-yl)guanidine

Product 1

HCID 178512249HCID 178512249, compoundYield 161.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 9.33 gm of 2-guanidino-4-(3-amino-phenyl)-thiazole and 3.93 gm of ethyl N-cyano-formamidate in 65 ml of ethanol was stirred at room temperature overnight. The crystalline product which separated out was collected by filtration, washed with cold ethanol and dried, yielding 9.2 gm of the title compound, mp. 215° C. (dec.)

Workup

  1. customThe crystalline product which separated out
  2. filtrationwas collected by filtration
  3. washwashed with cold ethanol
  4. customdried

Sources & evidence

ORD record
ord-e81b8c69661b44d2a1fe9261b02fbaf3
Source dataset
uspto-grants-1985_10
Patent number
US04548944

Reaction notes

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