Water → HCID 178512607, compound

HRID 464701Notes

Reaction equation

HRID 464701 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[C:6](=O)[CH2:7]Br)([O-:3])=[O:2].[C:14]([NH:17][C:18]([NH2:20])=[S:19])(=[NH:16])[NH2:15].O.[OH-].[Na+]>CN(C)C=O>[NH:17]([C:18]1[S:19][CH:7]=[C:6]([C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N+:1]([O-:3])=[O:2])[N:20]=1)[C:14]([NH2:16])=[NH:15]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 2440252-Bromo-2'-nitroacetophenoneHCID 178513045HCID 178513045, compound

Product 1

HCID 178512607HCID 178512607, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 16.5 gm of 2-nitro-phenacyl bromide and 7.98 gm of amidinothiourea in 70 ml of dimethylformamide was stirred at room temperature for 16 hours, and then poured into 350 ml of water. The solution was made alkaline with 10% sodium hydroxide, and the solid which separated out after cooling was filtered, washed with water and dried, yielding 16.9 gm of the title compound, m.p. 176°-178° C.

Workup

  1. customthe solid which separated out
  2. temperatureafter cooling
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-70e6d7e3ab7d49efa05a20b5c7311a8f
Source dataset
uspto-grants-1985_10
Patent number
US04548944

Reaction notes

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