HCID 70479432, compound → HCID 57131503, compound

HRID 464712Notes

Reaction equation

HRID 464712 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][CH:10]([O:21][C:22](=[O:30])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:11]([O:13]CC1C=CC=CC=1)=[O:12]>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][CH:10]([O:21][C:22](=[O:30])[CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:11]([OH:13])=[O:12]

Participants

4

Reactant 1

HCID 70479432HCID 70479432, compound

Product 1

HCID 57131503HCID 57131503, compoundYield 65.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

45.28 g (0.102 moles ) of benzyl 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetate prepared above were dissolved in 1500 ml of ethyl acetate, and the resulting mixture was mixed with 7 g of Pd/C 10% and then hydrogenated at atmospheric pressure for 14 hours. The solution was then filtered, concentrated and crystallized, thereby obtaining 23.51 g (65%) of 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid.

Workup

  1. filtrationThe solution was then filtered
  2. concentrationconcentrated
  3. customcrystallized

Sources & evidence

ORD record
ord-cc9650ed3d0b44e68f759c1293ce5fd6
Source dataset
uspto-grants-1985_10
Patent number
US04548952

Reaction notes

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