反应详情

A mixture of 100 g of indanone, 112 g of p-chlorobenzaldehyde and 500 ml of ethanol is stirred, the resulting solution is cooled to -10° and treated rapidly (3 minutes) with a solution of 5.0 g of KOH in 100 ml of ethanol. The solution is allowed to warm and the product begins to crystallize at 17° (cooled to keep under 15°). The resulting slurry is allowed to stir at 20°-25° for 1 hour, and then poured onto 2 liters of icewater. After standing for 3 hours, the solid is filtered, washed with cold water and allowed to air dry; wt., 190 g, m.p. 174°-179°. After crystallization from 400 ml of DMF, the cream-colored solid weighs 164.5 g (86%), m.p. 177°-179°.

1. temperaturethe resulting solution is cooled to -10°
2. temperatureto warm
3. customto crystallize at 17°
4. temperature(cooled to keep under 15°)
5. stirringto stir at 20°-25° for 1 hour
6. additionpoured onto 2 liters of icewater
7. filtrationthe solid is filtered
8. washwashed with cold water
9. customto air dry
10. customAfter crystallization from 400 ml of DMF