HCID 178464212, compound → HCID 13209198, compound

HRID 464769Notes

Reaction equation

HRID 464769 reaction equation
[CH3:1][O:2][C:3](=[O:20])[C:4](=[CH:16][NH:17][CH2:18][CH3:19])[C:5](=[O:15])[CH:6]=[CH:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1>CN(C)C=O>[CH3:1][O:2][C:3](=[O:20])[C:4]1[C:5](=[O:15])[CH2:6][CH:7]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[N:17]([CH2:18][CH3:19])[CH:16]=1

Participants

3

Reactant 1

HCID 178464212HCID 178464212, compound

Product 1

HCID 13209198HCID 13209198, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5.2 g. of 2-(ethylaminomethylene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester in 50 ml. of dimethylformamide were held at 140°-150° C. for 3 hours. After removal of the solvent, there were obtained 1-ethyl-6-(4-chlorophenyl)-4-oxo-1,4,5,6-tetrahydronicotinic acid methyl ester in the form of a uniform oily residue.

Workup

  1. customAfter removal of the solvent

Sources & evidence

ORD record
ord-163ed64176b54ef7b1774582e0598df4
Source dataset
uspto-grants-1985_10
Patent number
US04549022

Reaction notes

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