Ammonia → L-Phenylalanine

Participants

Reaction Steps

In a 100 l-volume hasteroi-made autoclave was placed 7.2 kg (30 moles) of a potassium bisulfite addition salt of phenylacetaldehyde, 1.76 kg (35.9 moles) of sodium cyanide, 4.32 kg (45 mole) of ammonium carbonate, 6 l (90 mole) of a 25% aqueous ammonia, 9 l of methanol and 24 l of water and the mixture was reacted at 100° C. for 2 hours to obtain precursors of phenylalanine. After the ammonia and methanol were removed by heating the reaction solution, the hydrolysis was carried out at 150° C. for 1.0 hour using 4.8 kg (120 moles) of caustic soda.

Provenance & Evidence