反应详情

温度

20 °C

30.0 g of N-(3,5-bis-trifluoromethyl-phenyl)-N'-methyl-thiourea were stirred in 100 ml of 1,2-dimethoxyethane and 10 ml of triethylamine, and then 22 g of a 30% strength aqueous glyoxal solution were added. The thiourea thereupon dissolved, the reaction being exothermic. The solution was stirred for a further 12 hours at 20° C. and was concentrated in vacuo and the residue was stirred with water and a little acetic acid. The reaction product, which had solidified, was filtered off, washed and dried. Yield 32.0 g; melting point: 133°-135° C. after recrystallisation from toluene.

1. concentrationwas concentrated in vacuo
2. stirringthe residue was stirred with water
3. filtrationwas filtered off
4. washwashed
5. customdried
6. custommelting point: 133°-135° C. after recrystallisation from toluene