反应详情

To 60 ml of absolute methyl alcohol were added 10 g of 4-phenoxy-2-butyl tosylate and 9.62 g of diethylamine. The mixture was reacted in a sealed tube for one hour at 125° C. After the reaction solution was condensed under reduced pressure, 100 ml of diethyl ether was added into the solution and the solution was separated with 20% aqueous sodium hydroxide solution. The ether layer was dried with anhydrous sodium sulfate, and the ether was removed under reduced pressure therefrom. The residue thus obtained was subjected to alumina-column chromatography using chloroform as the solvent to give 5.32 g of 1-methyl-3-phenoxypropyldiethylamine in a yield of 77%.

1. customThe mixture was reacted in a sealed tube for one hour at 125° C
2. additionwas added into the solution
3. customthe solution was separated with 20% aqueous sodium hydroxide solution
4. dry with materialThe ether layer was dried with anhydrous sodium sulfate
5. customthe ether was removed under reduced pressure
6. customThe residue thus obtained