Hydrochloric Acid → 3-(2-Piperidinoethylamino)indazole hydrochloride

HRID 464816Notes

Reaction equation

HRID 464816 reaction equation
[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[NH:12][N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:19].C(OCC)C>C(O)C>[ClH:19].[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[NH:12][N:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 30680421H-Indazol-3-amine, N-(2-(1-piperidinyl)ethyl)-

Product 1

HCID 233240393-(2-Piperidinoethylamino)indazole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 4.0 g of 3-(2-piperidinoethylamino)indazole and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Anhydrous diethyl ether was added to the solution to separate crystals. Then the crystals were obtained by filtration and dried to give 3-(2-piperidinoethylamino)indazole hydrochloride.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-1d3302ac9ac74cf3895b2a35d4b175cb
Source dataset
uspto-grants-1985_10
Patent number
US04549023

Reaction notes

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