Hydrogen chloride-ethyl acetate → HCID 13622606, compound

HRID 464855Notes

Reaction equation

HRID 464855 reaction equation
C(O[CH:6]([N:38]=C=O)[CH2:7][CH2:8][CH2:9][CH2:10][C@H:11]([NH:17][C@@H:18]1[C:24](=[O:25])[N:23]([CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])[C:22]2[CH:34]=[CH:35][CH:36]=[CH:37][C:21]=2[O:20][CH2:19]1)[C:12]([O:14][CH2:15][CH3:16])=[O:13])(C)(C)C.C(OCC)(=O)C.[ClH:47]>>[ClH:47].[ClH:47].[NH2:38][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C@H:11]([NH:17][C@@H:18]1[C:24](=[O:25])[N:23]([CH2:26][C:27]([OH:29])=[O:28])[C:22]2[CH:34]=[CH:35][CH:36]=[CH:37][C:21]=2[O:20][CH2:19]1)[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86740384HCID 86740384, compound

Product 1

HCID 13622606HCID 13622606, compound

Procedure

A solution of tert-butyl 3(S)-[6-tert-butoxy-carbonylamino-1(S)-ethoxycarbonylhexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (0.5 g) in 5N hydrogen chloride-ethyl acetate solution (10 ml) is allowed to stand for 3.5 hours at room temperature. Petroleum ether (80 ml) is added to the solution, and the resulting precipitate is collected and dried in vacuo to give 3(S)-[6-amino-1(S)-ethoxycarbonylhexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid dihydrochloride (0.4 g) as colorless powder.

Workup

  1. customthe resulting precipitate is collected
  2. customdried in vacuo

Sources & evidence

ORD record
ord-a7661440d5b14695aafc400d02340476
Source dataset
uspto-grants-1985_10
Patent number
US04548932

Reaction notes

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