Hydrogen chloride-ethyl acetate → HCID 13622606, compound

Participants

Reaction Steps

A solution of tert-butyl 3(S)-[6-tert-butoxy-carbonylamino-1(S)-ethoxycarbonylhexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (0.5 g) in 5N hydrogen chloride-ethyl acetate solution (10 ml) is allowed to stand for 3.5 hours at room temperature. Petroleum ether (80 ml) is added to the solution, and the resulting precipitate is collected and dried in vacuo to give 3(S)-[6-amino-1(S)-ethoxycarbonylhexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid dihydrochloride (0.4 g) as colorless powder.

Provenance & Evidence