Hydrochloric Acid → HCID 445692, compound

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Carbamic acid, [(1S,2S)-4-amino-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-, 1,1-dimethylethyl ester	HCID 56622520	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 445692	HCID 445692	—

Reaction Steps

Meanwhile, a mixture of 137 mg. (0.5 mmole) of (3S,4S)-4-t-butoxycarbonylamino-3-hydroxy-6-methylheptanoic acid amide and 5 ml. of 6N hydrochoric acid in dioxane was stirred under a nitrogen atmosphere for 20 minutes and then evaporated under reduced pressure to dryness. The residue was dissolved in 2 ml. of dimethylformamide and 0.05 g. of N-methylmorpholine was then added to form a solution of (3S,4S)-4-amino-3-hydroxy-6-methylheptanamide.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04548926
Source dataset	uspto-grants-1985_10
ORD ID	ord-c755f5cf3da6426490c5aec4819d4a7f
Source note	uspto-grants-1985_10