Hydrochloric Acid → HCID 445692, compound

HRID 464908Notes

Reaction equation

HRID 464908 reaction equation
C(OC([NH:8][C@@H:9]([CH2:16][CH:17]([CH3:19])[CH3:18])[C@@H:10]([OH:15])[CH2:11][C:12]([NH2:14])=[O:13])=O)(C)(C)C.Cl>O1CCOCC1>[NH2:8][C@@H:9]([CH2:16][CH:17]([CH3:19])[CH3:18])[C@@H:10]([OH:15])[CH2:11][C:12]([NH2:14])=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56622520Carbamic acid, [(1S,2S)-4-amino-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-, 1,1-dimethylethyl ester

Product 1

HCID 445692HCID 445692, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Meanwhile, a mixture of 137 mg. (0.5 mmole) of (3S,4S)-4-t-butoxycarbonylamino-3-hydroxy-6-methylheptanoic acid amide and 5 ml. of 6N hydrochoric acid in dioxane was stirred under a nitrogen atmosphere for 20 minutes and then evaporated under reduced pressure to dryness. The residue was dissolved in 2 ml. of dimethylformamide and 0.05 g. of N-methylmorpholine was then added to form a solution of (3S,4S)-4-amino-3-hydroxy-6-methylheptanamide.

Workup

  1. additionMeanwhile, a mixture of 137 mg
  2. customevaporated under reduced pressure to dryness
  3. dissolutionThe residue was dissolved in 2 ml
  4. additionof N-methylmorpholine was then added

Sources & evidence

ORD record
ord-c755f5cf3da6426490c5aec4819d4a7f
Source dataset
uspto-grants-1985_10
Patent number
US04548926

Reaction notes

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