反应详情

trans-4-Phenyl-3-buten-2-one (14.6 g, 0.1 mole), dimethylamine hydrochloride (9.0 g, 0.1 mole) and paraformaldehyde (5.8 g, 0.2 mole) are heated at reflux in 150 ml of absolute ethanol for 3 hours. The reaction mixture is concentrated in vacuo, then washed with ether. Addition of ethyl acetate causes crystallization. The product is recrystallized from acetonitrile to yield 6.9 g, m.p. 150°-154° C.

1. concentrationThe reaction mixture is concentrated in vacuo
2. washwashed with ether
3. additionAddition of ethyl acetate
4. customcrystallization
5. customThe product is recrystallized from acetonitrile
6. customto yield 6.9 g, m.p. 150°-154° C.