Isopropanol → (3-Trifluoromethyl-1,2,4-thiadiazol-5-yl)-oxyacetic acid diethylamide
Reaction equation
Cl[C:2]1[S:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[N:3]=1.[CH2:11]([N:13]([CH2:18][CH3:19])[C:14](=[O:17])[CH2:15][OH:16])[CH3:12].[OH-].[K+].C(O)(C)C>O>[CH2:11]([N:13]([CH2:18][CH3:19])[C:14](=[O:17])[CH2:15][O:16][C:2]1[S:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[N:3]=1)[CH3:12]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- -10 °C
Procedure
5.6 g (0.03 mol) of 5-chloro-3-trifluoromethyl-1,2,4-thiadiazole are added to a mixture which comprises 4 g (0.03 mol) of hydroxyacetic acid diethylamide, 1.9 g (0.03 mol) of potassium hydroxide powder and 80 ml of isopropanol and has been cooled to -10° C. The reaction mixture is stirred for 10 hours at -10° C. and poured into water, and the product is filtered off under suction. 4 g (47% of theory) of (3-trifluoromethyl-1,2,4-thiadiazol-5-yl)-oxyacetic acid diethylamide are obtained in the form of white crystals of melting point 60° C.
Workup
- filtrationthe product is filtered off under suction
Sources & evidence
- ORD record
- ord-21355d72c54840299639fa86057640b6
- Source dataset
- uspto-grants-1985_10
- Patent number
- US04549899
Reaction notes
Loading…