反应详情

A mixture of 9.6 g (23 mmole) of 1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-3-phthalimidopropyne and 1 teaspoonful of Raney nickel in 70 ml of tetrahydrofuran was hydrogenated at room temperature and atmospheric pressure. When 1.05 L of hydrogen was absorbed the catalyst was separated by filtration and the filtrate was concentrated at reduced pressure to dryness. The residue crystallized from a mixture of ether and petroleum ether to give the product as a tan solid, mp 98°-99° C.

1. customwas hydrogenated at room temperature
2. customWhen 1.05 L of hydrogen was absorbed the catalyst
3. customwas separated by filtration
4. concentrationthe filtrate was concentrated at reduced pressure to dryness
5. customThe residue crystallized from a mixture of ether and petroleum ether