反应详情

2'-Chloro-4'-nitrovaleranilide (13.0 g.) is dissolved in warm glacial acetic acid (100 ml.) and iron powder (14 g.) is added portionwise to maintain gentle boiling. The resulting reaction mixture is refluxed for one-half hour and filtered. The filtrate is evaporated under reduced pressure and the residue is triturated with water. The solid that forms is collected (11.5 g.) and recrystallized from cyclohexane to yield 7.5 g., m.p. 96.5°-99° C.

1. temperatureto maintain gentle boiling
2. customThe resulting reaction mixture
3. temperatureis refluxed for one-half hour
4. filtrationfiltered
5. customThe filtrate is evaporated under reduced pressure
6. customthe residue is triturated with water
7. customThe solid that forms is collected (11.5 g.)
8. customrecrystallized from cyclohexane
9. customto yield 7.5 g