反应详情

温度

-20 °C

A solution of 25 g of 2,3-epoxy-1,2,3,4-tetrahydronaphthalene in 250 ml ether is added to a solution of 2-pyridyl lithium (prepared from 2-bromopyridine and butyllithium) cooled to -20° C. After addition, the mixture is allowed to come to room temperature over several hours, then cooled again and treated with water. The separated, dried organics are taken to dryness, and the product purified by chromatography in neutral alumina.

1. additionAfter addition
2. waitto come to room temperature over several hours
3. temperaturecooled again
4. customthe product purified by chromatography in neutral alumina