HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 46503Generated: October 25, 2026
Water → 2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine
https://huagongshe.com/reaction/46503
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2,3-Epoxy-1,2,3,4-tetrahydronaphthalene | HCID 10888051 | — |
| Reactant | HCID 178506720 | HCID 178506720 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine | HCID 20387380 | — |
Reaction Steps
A solution of 25 g of 2,3-epoxy-1,2,3,4-tetrahydronaphthalene in 250 ml ether is added to a solution of 2-pyridyl lithium (prepared from 2-bromopyridine and butyllithium) cooled to -20° C. After addition, the mixture is allowed to come to room temperature over several hours, then cooled again and treated with water. The separated, dried organics are taken to dryness, and the product purified by chromatography in neutral alumina.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04173640 |
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| Source dataset | uspto-grants-1979_11 |
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| ORD ID | ord-e020e1f78509438189a408ee230a55d1 |
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| Source note | uspto-grants-1979_11 |
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