Hydrogen Bromide → HCID 13453079, compound

HRID 465041Notes

Reaction equation

HRID 465041 reaction equation
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([CH2:11]O)[CH:8]=[CH:7][C:5]=2[N:6]=1.Br.Cl.[NH2:15][CH2:16][CH2:17][SH:18]>>[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([CH2:11][S:18][CH2:17][CH2:16][NH2:15])[CH:8]=[CH:7][C:5]=2[N:6]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 9082Cysteamine HydrochlorideHCID 12902833HCID 12902833, compound

Product 1

HCID 13453079HCID 13453079, compound

Procedure

2-amino-5-hydroxymethylbenzimidazole (2.5 g) prepared according to the method described in Ger. offen. 2,528,846 (1976) and an aqueous 47% hydrobromic acid solution (25 ml) of cysteamine hydrochloride (1.3 g) were subjected to refluxing with heating for five hrs thereby to yield 2-amino-5-[(2-aminoethyl)thiomethyl]benzimidazole.3hydrobromate (melting point: 262°-265° C. (decomposition), 3 g).

Workup

  1. temperatureto refluxing
  2. temperaturewith heating for five hrs

Sources & evidence

ORD record
ord-7b5608b3961e4460bc5d2936a8a385b9
Source dataset
uspto-grants-1985_10
Patent number
US04550118

Reaction notes

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