HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 6-Ethoxycarbonyl-2-dimethylaminomethylbenzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 2-methyl-1,3-benzothiazole-6-carboxylate | HCID 640775 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 6-Ethoxycarbonyl-2-dimethylaminomethylbenzothiazole | HCID 20261657 | 32% |
Reaction Steps
6-ethoxycarbonyl-2-methylbenzothiazole (2.09 g) prepared according to the method described in J. Gen. Chem. vol. 5, pp. 260-266 (1945) was subjected to bromination with NBS (1.78 g) in carbon tetrachloride (30 mg). Then, the product was caused to react with dimethylamine to yield a new compound of 6-ethoxycarbonyl-2-dimethylaminomethylbenzothiazole (0.8 g). Then, the compound was provided with the same treatment as that described in Examples 49-51 to yield 6-[(2-aminoethyl)thiomethyl]-2-(dimethylaminomethyl)benzothiazole.2hydrobromide (1.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04550118 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-e5b996a123ce4f00ab642a722feae493 |
| Source note | uspto-grants-1985_10 |