Sodium → HCID 178512599, compound

HRID 465045Notes

Reaction equation

HRID 465045 reaction equation
Br.Br[CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]([NH:12][C:13]([NH2:15])=[NH:14])=[N:9][C:8]=2[CH:16]=1.[Na]>>[NH2:9][CH2:8][CH2:7][S:11][CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]([NH:12][C:13]([NH2:15])=[NH:14])=[N:9][C:8]=2[CH:16]=1

Participants

3

Reactant 2

HCID 5360545SodiumHCID 178419713HCID 178419713, compound

Product 1

HCID 178512599HCID 178512599, compound

Procedure

Cysteamine.hydrochloride (0.4 g) was caused to react with sodium ethoxide in ethanol to yield a sodium salt. Then, 5-bromomethyl-2-guanidinobenzothiazole.hydrobromide (0.63 g) was added to the sodium salt at an internal temperature of 0° C. After agitating the mixture over one night at room temperature, the solvent was removed, and the residue was made acidic with addition of dilute hydrochloric acid. The crystalline precipitate was collected to obtain 5-[(2-aminoethyl)thiomethyl]-2-guanidinobenzothiazole.2hydrochloride (0.5 g).

Workup

  1. customthe solvent was removed
  2. additionthe residue was made acidic with addition of dilute hydrochloric acid
  3. customThe crystalline precipitate was collected

Sources & evidence

ORD record
ord-5a7c41eac8dc4520adb61cd63edf6204
Source dataset
uspto-grants-1985_10
Patent number
US04550118

Reaction notes

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