11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → HCID 178482789, compound

HRID 465059Notes

Reaction equation

HRID 465059 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].[OH:21][C@H:22]1[CH2:27][CH2:26][C@H:25]([N:28]([CH2:30][CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][NH:32]2)[CH3:29])[CH2:24][CH2:23]1>C(#N)C>[OH:21][C@H:22]1[CH2:23][CH2:24][C@H:25]([N:28]([CH2:30][CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][N:32]2[CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[N:20][C:6]2=3)=[O:4])[CH3:29])[CH2:26][CH2:27]1

Participants

4

Reactant 2

HCID 12005311-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 178482790HCID 178482790, compound

Product 1

HCID 178482789HCID 178482789, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared analogously to Example 2 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and trans-2-[[(4-hydroxycyclohexyl)(methyl)-amino]methyl]piperidine to give colorless crystals, mp. 183°-184.5° C. (acetonitrile).

Sources & evidence

ORD record
ord-e62643dadd874beeaad0969a6a02298f
Source dataset
uspto-grants-1985_10
Patent number
US04550107

Reaction notes

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