HRID465069

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID120053

11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one

C14H10ClN3O2

HCID254287

N,N-Diethyl-2-piperidinemethanamine

C10H22N2

PRODUCTS

生成物

结构：CCN(CC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21

HCID107867

AF-DX 116

C24H31N5O2

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

First, 11-(chloroacetyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one (5.0 g, 0.0174 mol) is dissolved in anhydrous dioxan (100 ml) and refluxed for 2 hours after the addition of 2-[(diethylamino)methyl]piperidine (6.0 g, 0.035 mol).

WORKUP

后处理

temperaturerefluxed for 2 hours