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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 465069Generated: October 25, 2026

11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → 11-(2-(2-((Diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one

https://huagongshe.com/reaction/465069

Reaction equation

Participants

RoleNameHCIDCharge
Reactant11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 120053—
ReactantN,N-Diethyl-2-piperidinemethanamineHCID 254287—
Solvent1,4-DioxaneHCID 31275—
Product11-(2-(2-((Diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 107867—

Reaction Steps

First, 11-(chloroacetyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]benzodiazepin-6-one (5.0 g, 0.0174 mol) is dissolved in anhydrous dioxan (100 ml) and refluxed for 2 hours after the addition of 2-[(diethylamino)methyl]piperidine (6.0 g, 0.035 mol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04550107
Source datasetuspto-grants-1985_10
ORD IDord-cb1a2f7441e74332800d626946540bac
Source noteuspto-grants-1985_10