HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → (S)-5,11-Dihydro-11-[[2-[(1-pyrrolidinyl)methyl]-1-pyrrolidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one | HCID 120053 | — |
| Reactant | (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853152 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-5,11-Dihydro-11-[[2-[(1-pyrrolidinyl)methyl]-1-pyrrolidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 13578576 | — |
Reaction Steps
The title compound is prepared analogously to Example 31 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and (S)-(+)-2-[(1-pyrrolidinyl)methyl]pyrrolidine to give colorless crystals, mp. 192°-193° C. (ethyl acetate). [α]D20 =-18.1° (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04550107 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-926850534af8480e9d6b71f8d154c4bc |
| Source note | uspto-grants-1985_10 |