Diethyl-piperidin-3-ylmethyl-amine → HCID 20261521, compound

HRID 465076Notes

Reaction equation

HRID 465076 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[CH:20][C:6]1=2)=[O:4].[CH2:21]([N:23]([CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][NH:29][CH2:28]1)[CH2:24][CH3:25])[CH3:22]>C(O)(C)C.C(OCC)(=O)C>[OH2:4].[OH2:4].[ClH:1].[ClH:1].[CH2:21]([N:23]([CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][N:29]([CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[CH:20][C:6]2=3)=[O:4])[CH2:28]1)[CH2:24][CH3:25])[CH3:22]

Participants

4

Reactant 2

HCID 6484181Diethyl-piperidin-3-ylmethyl-amineHCID 100854195-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Product 1

HCID 20261521HCID 20261521, compound

Reagents, catalysts & solvents 1

HCID 22055037Isopropanol ethyl acetateSolvent

Procedure

The title compound is prepared analogously to Example 35 from 5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 3-[(diethylamino)methyl]piperidine to give colorless crystals, mp. 140° C. (isopropanol/ethyl acetate).

Sources & evidence

ORD record
ord-435e844b91db4008a5738ff58e74d73f
Source dataset
uspto-grants-1985_10
Patent number
US04550107

Reaction notes

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