Methyl iodide → HCID 23471442, compound

HRID 465094Notes

Reaction equation

HRID 465094 reaction equation
[OH:1][CH:2]([CH3:10])[CH2:3][N:4]1[CH2:8][CH2:7][NH:6][C:5]1=[S:9].[CH3:11][I:12]>CC(O)C>[IH:12].[CH3:10][CH:2]([OH:1])[CH2:3][N:4]1[CH2:8][CH2:7][N:6]=[C:5]1[S:9][CH3:11]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 123262511-(2-Hydroxypropyl)-2-imidazolidinethione

Product 1

HCID 23471442HCID 23471442, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
-10 °C

Procedure

A solution composed of 32.0 g of 1-(2-hydroxypropyl)-2-imidazolidinethione, 250 ml of 2-propanol and 15 ml of methyliodide was stirred at reflux for 4 hours, then clarified, cooled at -10° C. and the solid collected, washed with 2-propanol, then ether and dried at 60° C. in vacuo, giving 52.7 g of α-methyl-2-(methylthio)-2-imidazoline-1-ethanol, hydroiodide, mp 114°-116° C.

Workup

  1. temperatureat reflux for 4 hours
  2. customthe solid collected
  3. washwashed with 2-propanol
  4. dry with materialether and dried at 60° C. in vacuo

Sources & evidence

ORD record
ord-fb7048eecac8406e83580c1c2193f7b6
Source dataset
uspto-grants-1985_10
Patent number
US04550169

Reaction notes

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