HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 465097Generated: October 29, 2026
Ethanol → 2-(Ethylthio)-1,4,5,6-tetrahydro-5-pyrimidinol, hydrobromide
https://huagongshe.com/reaction/465097
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl Bromide | HCID 6332 | — |
| Reactant | 5-Hydroxytetrahydropyrimidine-2(1H)-thione | HCID 3574639 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-(Ethylthio)-1,4,5,6-tetrahydro-5-pyrimidinol, hydrobromide | HCID 131714394 | — |
Reaction Steps
A mixture of 26.4 g of tetrahydro-5-hydroxy-2(1H)-pyrimidinethione, 30 ml of ethyl bromide and 250 ml of ethanol was refluxed for 7 hours, clarified, diluted with 250 ml of ether and cooled to -10° C. The solid was crystallized twice from ether, giving 19.5 g of 2-(ethylthio)-1,4,5,6-tetrahydro-5-pyrimidinol, hydrobromide, mp 106°-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04550169 |
|---|
| Source dataset | uspto-grants-1985_10 |
|---|
| ORD ID | ord-4a45fa98262c40e984fef2262e011b21 |
|---|
| Source note | uspto-grants-1985_10 |
|---|
