反应详情

温度

-10 °C

A mixture of 26.4 g of tetrahydro-5-hydroxy-2(1H)-pyrimidinethione, 30 ml of ethyl bromide and 250 ml of ethanol was refluxed for 7 hours, clarified, diluted with 250 ml of ether and cooled to -10° C. The solid was crystallized twice from ether, giving 19.5 g of 2-(ethylthio)-1,4,5,6-tetrahydro-5-pyrimidinol, hydrobromide, mp 106°-108° C.

1. temperaturewas refluxed for 7 hours
2. customThe solid was crystallized twice from ether