反应详情

温度

20 °C

A 0.2 g portion of α-ethylidene 3-pyridine acetonitrile and 0.315 ml of t-butoxy-bis-dimethylaminomethane were dissolved in tetrahydrofuran and stirred at 20° C. for 20 hours. The solvent was removed at reduced pressure and the orange oil was purified by chromatography, eluting with ethyl acetate:hexane (10:3). The eluate was concentrated to a solid which was recrystallized from methylene chloride-hexane, giving α-[3-(dimethylamino)-2-propenylidene]-3-pyridineacetonitrile as yellow crystals, mp 117°-120° C.

1. customThe solvent was removed at reduced pressure
2. customthe orange oil was purified by chromatography
3. washeluting with ethyl acetate:hexane (10:3)
4. concentrationThe eluate was concentrated to a solid which
5. customwas recrystallized from methylene chloride-hexane