Triethyl orthoacetate → 3-Methyl-8-(3-pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

Participants

Reaction Conditions

Reaction Steps

A 1.0 g portion of 2-hydrazino-3,3'-bipyridine was dissolved in 5 ml of triethyl orthoacetate and heated at 130° C. for 1.5 hours. The volatiles were removed at reduced pressure and the residue purified by chromatography on silica gel, eluting with ethyl acetate:methanol (9:2). The resulting solid was recrystallized from methylene chloride-hexane, giving the desired product as a tan powder, mp 112.5°-115° C.

Provenance & Evidence