Ethyl orthoformate → 8-(3-Pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

Participants

Reaction Conditions

Reaction Steps

A 4.15 g portion of 2-hydrazino-3,3'-bipyridine was dissolved in 30 ml of triethyl orthoformate and heated at 100° C. for 2 hours. The volatiles were removed at reduced pressure and the residue purified by chromatography on hydrous magnesium silicate, eluting with ethyl acetate. The solid was recrystallized from methylene chloride-hexane, giving 2.67 g of the desired product, mp 186°-189° C.

Provenance & Evidence