Hydrazine → HCID 13533706, compound

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Reaction Steps

As described in Example 5, 2.2 g of 6-chloro-3,3'-bipyridine was treated with 3.6 ml of anhydrous hydrazine in pyridine at 115° C. for 48 hours. The resulting crude 6-hydrazino-3,3'-bipyridine was dissolved in 25 ml of triethyl orthoformate and 2 drops of acetic acid and heated to 130° C. for 10 hours. The volatiles were removed at reduced pressure and the residue purified by chromatography on silica gel, eluting with ethyl acetate:methanol (9:2). The obtained solid was recrystallized from ethyl acetate-methanol, giving the desired product, mp 200°-202.5° C.

Provenance & Evidence