Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiophenol → 2-(Chloromethyl)benzothiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiophenol | HCID 8713 | — |
| 반응물 | O-methyl 2-chloroacetimidate | HCID 12680764 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(Chloromethyl)benzothiazole | HCID 304978 | 71% |
반응 단계
To a solution of aminothiophenol (8.3 g) in methylene chloride at 0° C. is added methyl chloroacetimidate hydrochloride1 (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water three times; dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120°-135° C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04550172 |
| 출처 데이터셋 | uspto-grants-1985_10 |
| ORD ID | ord-079b659fcb014e8d9dd3b2cc8a968be4 |
| 출처 메모 | uspto-grants-1985_10 |