HRID465202

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

HCID581157

[2-(2-Chloroacetamido)-1,3-thiazol-4-yl](methoxyimino)acetic acid

C8H8ClN3O4S

结构：CN1CN(S[C@@H]2NC(=O)[C@H]2NC(c2ccccc2)(c2ccccc2)c2ccccc2)N=N1

HCID54359258

未命名化合物

PRODUCTS

生成物

结构：CON=C(C(=O)N[C@@H]1C(=O)N[C@H]1SN1CN(C)N=N1)c1csc(NC(=O)CCl)n1

HCID57003025

未命名化合物

收率 55.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Following the procedure of Reference Example 66B, solution of 1.12 g of (3R,4S)-4-(1-methyl-1H-tetrazol-4-yl)thio-3-tritylamino-2-oxoazetidine in 5 ml of acetone, 0.491 g of p-toluenesulfonic acid monohydrate and 0.788 g of 2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetic acid is treated to give 0.650 g of (3R,4S)-3-[2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetamido]-4-(1-methyl-1H-tetrazol-4-yl)thio-2-oxoazetidine.

WORKUP

后处理

additionis treated